ZETA PLUS ® VR SERIES Viral Reduction Depth Filters 
VR Series For Enhanced Log Reduction of Viruses From Biological Fluids

FEATURES
Combined ion exchange & physical entrapment virus removal mechanisms
Quality Control tested for media ion exchange capacity u Self-contained, single-use disposable
     capsules & cartridge modules
Range of cartridge sizes, sanitary design cartridge housings & disposable capsules
Optimized cartridge designs for biologicals filtration
Complete technical, regulatory & validation support
Economical “bolt-on” separation technology as adjunct or pre-filter to other viral clearance steps

BENEFITS
Validatable viral log reduction 
Provides added level of viral safety
Assurance of filter media consistency & performance
Single-use, disposable design eliminates validation concerns associated with reusable clearance
     options (chromatography column sanitization & regeneration)
Eliminates concern over virus carryover from one purification cycle to the next
Facilitates scaleup from small volume feasibility trials & validation studies to production 
    scale operations
Enable high flow processes
Robust in-situ steam-sterilizable cartridges
Drug Master Files simplify FDA submissions
Regulatory Support Files detail filter media regulatory compliance & safety data
Provides added level of validatable viral clearance
Can replace or augment chromatography columns or function as prefilter to final virus 
     removal membrane filter

APPLICATION
The removal and/or inactivation of contaminating viruses from biotherapeutics is a requisite for ensuring final product safety. Zeta Plus VR cartridge depth filters remove significant levels of viruses from biological fluids. They provide validatable viral titer reduction, high flow rates, scalability, economy, disposability and ease-of-use in the biological manufacturing environment. The VR Series includes specific filter media recommendations for virus removal from blood plasma proteins and bioprocess -derived cell culture fluids.

Virus Removal Applications for Zeta Plus VR Media:
Processing of human plasma-derived proteins
Recombinant proteins from cell culture and fermentation
Monoclonal antibodies
Serum and other raw materials derived from animal sources

Zeta Plus depth filtration offers an attractive and economical alternative to other available technologies for reduction of viral burden. Zeta Plus VR Series depth filters can be used as a bolt-on processing step to existing in-process viral clearance methodologies, providing an added measure of end-product safety.